tramadol and o desmethyltramadol enantiomers clinical trial intelligence

Comparative, Randomized, Double-Blind, Single-Dose, 2-way Crossover Study to Evaluate the Pharmacokinetics and Analgesic Effect of Labopharm Tramadol Contramid® OAD 200 mg Tablets or Placebo in Healthy Young and Elderly Adult Volunteers

This completed clinical trial evaluated the pharmacokinetics and pharmacodynamics of tramadol and its active metabolite, O-desmethyltramadol, in healthy young and elderly adults. The study aimed to understand age-related differences in drug metabolism and analgesic effects, which could inform dosing and safety profiles for geriatric patients.

Matched by target_normalized: Tramadol and O-desmethyltramadol enantiomers