Lysergic Acid Diethylamide (LSD) in Palliative Care: a Randomised, Double-blind, Active-placebo Controlled Phase II Study (LPC-Study)
The LPC-Study, sponsored by the University Hospital Basel, aims to evaluate the efficacy of LSD in alleviating psychosocial distress in terminally ill patients. Given the increasing interest in psychedelic-assisted therapies, this study positions itself within a burgeoning market for mental health treatments, particularly in palliative care. The potential to demonstrate significant improvements in quality of life and pain management could attract attention from pharmaceutical companies seeking to expand their portfolios in this area. However, the competitive landscape includes other psychedelic compounds like psilocybin, which are also being investigated for similar indications. Diligence should focus on regulatory pathways, potential market access challenges, and the evolving public perception of psychedelics in therapeutic contexts.
Indication: Palliative Care
Modality: small molecule
Target: Serotonin receptors (specifically 5-HT2A) and potential modulation of pain pathways.
Sponsor: University Hospital, Basel, Switzerland
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 18, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Serotonin receptors (specifically 5-HT2A) and potential modulation of pain pathways.
View original source fields
Condition raw: Palliative Care, Pain, Anxiety, Depression, Demoralization, Psychological Distress, Quality of Life, Caregiver Burden, Fear of Death, Existential Distress
Condition normalized: Palliative Care, Pain, Anxiety, Depression, Demoralization, Psychological Distress, Quality of Life, Caregiver Burden, Fear of Death, Existential Distress
Modality raw: small molecule
Modality normalized: small molecule
Target raw: Serotonin receptors (specifically 5-HT2A) and potential modulation of pain pathways.
Target normalized: Serotonin receptors (specifically 5-HT2A) and potential modulation of pain pathways.