L-carnitine Supplementation for Co-occurring Depression and Alcohol Use Disorder in Youth: An Open Trial Pilot Study
The primary objective of this study is to evaluate the effects of L-carnitine, 2.97g daily on alcohol cue-elicited alcohol craving during a human laboratory paradigm after 4 weeks of daily dosing among participants ages 18-25 with alcohol use disorder (AUD) as confirmed by the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5™) and who report at least mild depressive symptoms on the Beck Depression Inventory-II. Secondary objectives include evaluation of L-carnitine (2.97g/day) on alcohol craving and use, subjective effects of alcohol consumption, mood, sleep, alcohol use negative consequences, study retention, and safety and tolerability.
Indication: Alcohol Use Disorder
Modality: small molecule
Target: L-carnitine
Sponsor: Brown University
Source URL: ClinicalTrials.gov
Source updated: Jun 15, 2025
Ingested: Jun 08, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: L-carnitine
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Condition raw: Alcohol Use Disorder
Condition normalized: Alcohol Use Disorder
Modality raw: small molecule
Modality normalized: small molecule
Target raw: L-carnitine
Target normalized: L-carnitine