Effect of Mepolizumab on the Phenotype/Proteome/Transcriptome of Eosinophils in Severe Eosinophilic Asthma
Mepolizumab, an IL-5 antagonist, is being evaluated for its efficacy in severe eosinophilic asthma, a market segment with significant unmet needs. The study aims to identify predictive and prognostic biomarkers for treatment response, which could enhance patient stratification and improve therapeutic outcomes. Given the increasing prevalence of asthma and the growing demand for targeted biologics, successful outcomes could position mepolizumab favorably against competitors like dupilumab and other emerging therapies. The collaboration with GlaxoSmithKline indicates strong industry backing, potentially facilitating broader market access and commercialization strategies.
Indication: Asthma
Modality: small molecule
Target: IL-5 receptor (CD125) on eosinophils
Sponsor: Hospital Clinico Universitario de Santiago
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 10, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: IL-5 receptor (CD125) on eosinophils
View original source fields
Condition raw: Asthma, Eosinophilic Asthma
Condition normalized: Asthma, Eosinophilic Asthma
Modality raw: small molecule
Modality normalized: small molecule
Target raw: IL-5 receptor (CD125) on eosinophils
Target normalized: IL-5 receptor (CD125) on eosinophils