Metformin in Head and Neck Squamous Cell Carcinoma: A Window of Opportunity Study to Assess the Effect on Tissue Oxygenation
This study investigates the effect of Metformin on tissue oxygenation in patients with oral cavity squamous cell carcinoma. The trial aims to establish whether Metformin can reduce hypoxia in tumor tissues, potentially improving treatment outcomes and response to radiation therapy.
Indication: Head and Neck Cancer
Modality: small molecule
Target: Head and Neck Squamous Cell Carcinoma
Sponsor: Insel Gruppe AG, University Hospital Bern
Source URL: ClinicalTrials.gov
Source updated: Nov 18, 2021
Ingested: May 30, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Head and Neck Squamous Cell Carcinoma
View original source fields
Condition raw: Head and Neck Cancer
Condition normalized: Head and Neck Cancer
Modality raw: Head and Neck Cancer
Modality normalized: small molecule
Target raw: Head and Neck Squamous Cell Carcinoma
Target normalized: Head and Neck Squamous Cell Carcinoma