Quantitative Electroencephalography to Longitudinally Assess the Functional Brain Signature of Treatment-resistant Depression and Recovery With Therapeutic Neuromodulation
This clinical trial, sponsored by Sunnybrook Health Sciences Centre, investigates the efficacy of rTMS combined with dry quantitative EEG (qEEG) technology to personalize treatment for patients with treatment-resistant depression. The market for depression treatments is substantial, with increasing demand for innovative therapies that address unmet needs. The use of qEEG may provide a competitive edge by enabling real-time monitoring of brain activity and treatment response, potentially leading to improved patient outcomes and reduced relapse rates. Given the rising prevalence of depression globally, successful outcomes could position the sponsor favorably within the neuromodulation market, which is projected to grow significantly. Diligence should focus on the scalability of the qEEG technology and the regulatory landscape surrounding neuromodulation devices.
Indication: Major Depressive Diorder
Modality: medical device
Target: Dorsolateral prefrontal cortex (DLPFC) modulation via repetitive transcranial magnetic stimulation (rTMS) to restore brain network function in treatment-resistant depression.
Sponsor: Sunnybrook Health Sciences Centre
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 03, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Dorsolateral prefrontal cortex (DLPFC) modulation via repetitive transcranial magnetic stimulation (rTMS) to restore brain network function in treatment-resistant depression.
View original source fields
Condition raw: Major Depressive Diorder
Condition normalized: Major Depressive Diorder
Modality raw: medical device
Modality normalized: medical device
Target raw: Dorsolateral prefrontal cortex (DLPFC) modulation via repetitive transcranial magnetic stimulation (rTMS) to restore brain network function in treatment-resistant depression.
Target normalized: Dorsolateral prefrontal cortex (DLPFC) modulation via repetitive transcranial magnetic stimulation (rTMS) to restore brain network function in treatment-resistant depression.