An Open-label, Adaptive Design Study in Patients With Amyotrophic Lateral Sclerosis (ALS) to Characterize Safety, Tolerability and Brain Microglia Response, as Measured by TSPO Binding, Following Multiple Doses of BLZ945 Using Positron Emission Tomography (PET) With the Radioligand [11C]-PBR28
An Open-label, Adaptive Design Study in Patients With Amyotrophic Lateral Sclerosis (ALS) to Characterize Safety, Tolerability and Brain Microglia Response, as Measured by TSPO Binding, Following Multiple Doses of BLZ945 Using Positron Emission Tomography (PET) With the Radioligand [11C]-PBR28 is a PHASE2 clinical asset sponsored by Novartis Pharmaceuticals in Amyotrophic Lateral Sclerosis. SEO and diligence focus: BLZ945, endpoint relevance, enrollment feasibility, competitive positioning, readout timing and IP durability.
Indication: Amyotrophic Lateral Sclerosis
Modality: small molecule
Target: BLZ945
Sponsor: Novartis Pharmaceuticals
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 24, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: BLZ945
View original source fields
Condition raw: Amyotrophic Lateral Sclerosis
Condition normalized: Amyotrophic Lateral Sclerosis
Modality raw: small molecule
Modality normalized: small molecule
Target raw: BLZ945
Target normalized: BLZ945