Quantification of Bacterial DNA in Septic Intensive Care Patients in Relation to Concentration of Antibiotics and Clinical Outcome: A Prospective Observation Study
This study, sponsored by Region Örebro County, aims to establish ddPCR as a diagnostic tool for assessing bacterial load and treatment efficacy in septic patients. Given the high mortality rates associated with sepsis and the challenges in timely diagnosis and treatment, successful validation of this method could address significant unmet medical needs in critical care. The findings may enhance antibiotic stewardship and reduce the incidence of antibiotic resistance, positioning ddPCR as a valuable asset in the sepsis management market. The potential for commercialization hinges on demonstrating clinical utility and integration into existing diagnostic workflows, which could attract interest from diagnostic companies and pharmaceutical partners.
Indication: Septic Shock
Modality: RNA therapy
Target: Bacterial DNA clearance measured with droplet digital Polymerase Chain Reaction (ddPCR) as a biomarker for bacterial load in septic patients.
Sponsor: Region Örebro County
Source URL: ClinicalTrials.gov
Source updated: Jan 29, 2019
Ingested: Jun 17, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Bacterial DNA clearance measured with droplet digital Polymerase Chain Reaction (ddPCR) as a biomarker for bacterial load in septic patients.
View original source fields
Condition raw: Septic Shock, Sepsis Bacterial, Sepsis
Condition normalized: Septic Shock, Sepsis Bacterial, Sepsis
Modality raw: RNA therapy
Modality normalized: RNA therapy
Target raw: Bacterial DNA clearance measured with droplet digital Polymerase Chain Reaction (ddPCR) as a biomarker for bacterial load in septic patients.
Target normalized: Bacterial DNA clearance measured with droplet digital Polymerase Chain Reaction (ddPCR) as a biomarker for bacterial load in septic patients.