A Phase 3 Randomized, Open-label (Sponsor-blind), Active-controlled, Parallel-group, Multi-center, Event Driven Study in Dialysis Subjects With Anemia Associated With Chronic Kidney Disease to Evaluate the Safety and Efficacy of Daprodustat Compared to Recombinant Human Erythropoietin, Following a Switch From Erythropoietin-stimulating Agents
The ASCEND-D trial evaluated the safety and efficacy of daprodustat, a novel prolyl hydroxylase inhibitor, in treating anemia associated with chronic kidney disease (CKD) in dialysis patients. Conducted by GlaxoSmithKline, the study involved 2,964 participants across 431 centers in 35 countries, comparing daprodustat to recombinant human erythropoietin (rhEPO).
Indication: Anaemia
Modality: small molecule
Target: Anemia in Chronic Kidney Disease
Sponsor: GlaxoSmithKline
Source URL: ClinicalTrials.gov
Source updated: Dec 03, 2021
Ingested: May 30, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Anemia in Chronic Kidney Disease
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Condition raw: Anaemia
Condition normalized: Anaemia
Modality raw: Anaemia
Modality normalized: small molecule
Target raw: Anemia in Chronic Kidney Disease
Target normalized: Anemia in Chronic Kidney Disease