A Phase 1/2, Randomized, Double-blind, Placebo-controlled, Single Ascending and Multiple Dose Study of the Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of ALN-XDH in Healthy Adult Subjects and Adult Patients With Gout
The purpose of this study is to: * Part A: Evaluate the safety and tolerability of single ascending doses of ALN-XDH in healthy adult participants * Part B: Evaluate the safety, tolerability and efficacy of ALN-XDH as monotherapy in adult patients with gout * Part C: Evaluate the safety, tolerability and efficacy of ALN-XDH as add-on therapy in adult patients with gout
Indication: Gout
Modality: small molecule
Target: ALN-XDH, Placebo
Sponsor: Alnylam Pharmaceuticals
Source URL: ClinicalTrials.gov
Source updated: Mar 29, 2024
Ingested: Jun 11, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: ALN-XDH, Placebo
View original source fields
Condition raw: Gout
Condition normalized: Gout
Modality raw: small molecule
Modality normalized: small molecule
Target raw: ALN-XDH, Placebo
Target normalized: ALN-XDH, Placebo