An Open-Label, First-In-Human Study Evaluating the Safety and Tolerability of VCTX210A Combination Product in Subjects With Type 1 Diabetes Mellitus (T1D)
CRISPR Therapeutics AG is advancing VCTX210A, a novel combination product aimed at treating Type 1 Diabetes Mellitus (T1D) through a first-in-human trial. The market for T1D therapies is significant, with a growing demand for innovative treatments that address the autoimmune nature of the disease. The collaboration with ViaCyte enhances the potential for successful commercialization, leveraging their expertise in cell therapy. Given the competitive landscape, including traditional insulin therapies and emerging gene therapies, VCTX210A could position CRISPR Therapeutics favorably if safety and tolerability are confirmed. The completion of this Phase 1 trial is a critical step toward further clinical development and potential market entry.
Indication: Diabetes Mellitus
Modality: gene therapy
Target: Allogeneic pancreatic endoderm cells (PEC210A) genetically modified using CRISPR/Cas9 to promote immune evasiveness and survival.
Sponsor: CRISPR Therapeutics AG
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 10, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Allogeneic pancreatic endoderm cells (PEC210A) genetically modified using CRISPR/Cas9 to promote immune evasiveness and survival.
View original source fields
Condition raw: Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Disease, Endocrine System Diseases, Autoimmune Diseases, Immune System Diseases
Condition normalized: Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Disease, Endocrine System Diseases, Autoimmune Diseases, Immune System Diseases
Modality raw: gene therapy
Modality normalized: gene therapy
Target raw: Allogeneic pancreatic endoderm cells (PEC210A) genetically modified using CRISPR/Cas9 to promote immune evasiveness and survival.
Target normalized: Allogeneic pancreatic endoderm cells (PEC210A) genetically modified using CRISPR/Cas9 to promote immune evasiveness and survival.