The Use of Buffered Soluble Alendronate 70 mg (Steovess/Binosto) After Denosumab Discontinuation to Prevent Increase in Bone Turnover
It is hypothesized that effervescent alendronate will be able to maintain bone turnover markers within the pre-menopausal reference range and thereby reducing the likelihood of bone turnover associated changes (rebound effect), after discontinuation of denosumab treatment in a non-osteoporotic population.
Indication: Erosive Osteoarthritis
Modality: monoclonal antibody
Target: Alendronate Effervescent Oral Tablet
Sponsor: University Hospital, Ghent
Source URL: ClinicalTrials.gov
Source updated: Dec 13, 2024
Ingested: Jun 18, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by target_normalized: Alendronate Effervescent Oral Tablet
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Condition raw: Erosive Osteoarthritis
Condition normalized: Erosive Osteoarthritis
Modality raw: monoclonal antibody
Modality normalized: monoclonal antibody
Target raw: Alendronate Effervescent Oral Tablet
Target normalized: Alendronate Effervescent Oral Tablet