NCT02815813Source recordAI-normalized
Peer Support and Mobile Technology Targeting Cardiometabolic Risk Reduction in Young Adults With Serious Mental Illness
Peer Support and Mobile Technology Targeting Cardiometabolic Risk Reduction in Young Adults With Serious Mental Illness is a NA clinical asset sponsored by Dartmouth-Hitchcock Medical Center in Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder, Overweight, Obesity. SEO and diligence focus: PeerFIT, BEAT, endpoint relevance, enrollment feasibility, competitive positioning, readout timing and IP durability.
AI analysis
Indication: Schizophrenia
Modality: behavioral intervention
Target: PeerFIT, BEAT
Sponsor: Dartmouth-Hitchcock Medical Center
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 28, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Major Depressive Disorder
View original source fields
Condition raw: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder, Overweight, Obesity
Condition normalized: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder, Overweight, Obesity
Modality raw: behavioral intervention
Modality normalized: behavioral intervention
Target raw: PeerFIT, BEAT
Target normalized: PeerFIT, BEAT
NCT01731717Source recordAI-normalized
Effektivität Und Effizienz Von Behandlungspfaden für Patienten Mit Depressiven Erkrankungen: Stepped Care Als Ansatz für Ein Leitliniengerechtes Und Integriertes Versorgungsmanagement
Effektivität Und Effizienz Von Behandlungspfaden für Patienten Mit Depressiven Erkrankungen: Stepped Care Als Ansatz für Ein Leitliniengerechtes Und Integriertes Versorgungsmanagement is a NA clinical asset sponsored by Universitätsklinikum Hamburg-Eppendorf in Depression. SEO and diligence focus: Active monitoring, Bibliotherapy, Online self-help, Outpatient psychotherapy, Psychiatric treatment, Combined psychotherapy and psychopharmacological treatment, Control group: treatment as usual, endpoint relevance, enrollment feasibility, competitive positioning, readout timing and IP durability.
AI analysis
Indication: Depression
Modality: behavioral intervention
Target: Active monitoring, Bibliotherapy, Online self-help, Outpatient psychotherapy, Psychiatric treatment, Combined psychotherapy and psychopharmacological treatment, Control group: treatment as usual
Sponsor: Universitätsklinikum Hamburg-Eppendorf
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 28, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Depression
NCT05059392Source recordAI-normalized
Training for Awareness, Resilience and Action (TARA) for Medical Students: A Single-arm Mixed Methods Pilot Study to Evaluate an Indicated Prevention of Mental Disorders and Stress-related Symptoms
Training for Awareness, Resilience and Action (TARA) for Medical Students: A Single-arm Mixed Methods Pilot Study to Evaluate an Indicated Prevention of Mental Disorders and Stress-related Symptoms is a NA clinical asset sponsored by Umeå University in Depression, Anxiety, Stress-related Problem. SEO and diligence focus: Training for Awareness, Resilience and Action (TARA), endpoint relevance, enrollment feasibility, competitive positioning, readout timing and IP durability.
AI analysis
Indication: Depression
Modality: behavioral intervention
Target: Training for Awareness, Resilience and Action (TARA)
Sponsor: Umeå University
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 22, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Depression
View original source fields
NCT05229406Source recordAI-normalized
Healthy Minds Program (HMP) App Dosage Study
The Healthy Minds Program (HMP) App Dosage Study, sponsored by the University of Wisconsin, Madison, aims to evaluate the effectiveness of a meditation app in reducing symptoms of depression and anxiety. Given the rising prevalence of mental health issues and the increasing demand for accessible mental health solutions, this app could capture a significant share of the digital mental health market. The study's findings may position the HMP app favorably against competitors in the mHealth space, particularly those focusing on meditation and mindfulness. The collaboration with NIH and NCCIH enhances credibility and may facilitate future funding opportunities or partnerships. Diligence should focus on user engagement metrics, adherence rates, and comparative efficacy against existing solutions.
AI analysis
Indication: Depression
Modality: behavioral intervention
Target: Healthy Minds Program (HMP) meditation app targeting psychological well-being through meditation practices.
Sponsor: University of Wisconsin, Madison
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 21, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Depression
NCT05883540Source recordAI-normalized
Lysergic Acid Diethylamide (LSD) in Palliative Care: a Randomised, Double-blind, Active-placebo Controlled Phase II Study (LPC-Study)
The LPC-Study, sponsored by the University Hospital Basel, aims to evaluate the efficacy of LSD in alleviating psychosocial distress in terminally ill patients. Given the increasing interest in psychedelic-assisted therapies, this study positions itself within a burgeoning market for mental health treatments, particularly in palliative care. The potential to demonstrate significant improvements in quality of life and pain management could attract attention from pharmaceutical companies seeking to expand their portfolios in this area. However, the competitive landscape includes other psychedelic compounds like psilocybin, which are also being investigated for similar indications. Diligence should focus on regulatory pathways, potential market access challenges, and the evolving public perception of psychedelics in therapeutic contexts.
AI analysis
Indication: Palliative Care
Modality: small molecule
Target: Serotonin receptors (specifically 5-HT2A) and potential modulation of pain pathways.
Sponsor: University Hospital, Basel, Switzerland
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 18, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Depression
NCT07503951Source recordAI-normalized
Implementing Brief Cognitive Behavior Therapy in Psychiatric Inpatient Care Delivered by Mental Health Professionals
The trial, sponsored by Region Stockholm, aims to evaluate the implementation of Brief Cognitive Behavioral Therapy (CBT) in psychiatric inpatient care. Given the increasing demand for psychological interventions in inpatient settings and the documented benefits of CBT in outpatient care, this study addresses a significant gap in mental health treatment. The successful implementation of CBT could enhance patient outcomes, reduce readmission rates, and improve overall healthcare efficiency. The findings may position Region Stockholm as a leader in innovative mental health treatment, potentially influencing policy and funding for psychological therapies in inpatient care across Sweden and beyond. The market for mental health services is expanding, and effective interventions like CBT could attract funding and partnerships with healthcare providers and mental health organizations.
AI analysis
Indication: Depression, Anxiety Disorders
Modality: behavioral intervention
Target: Cognitive Behavioral Therapy (CBT) mechanisms targeting depressive symptoms and anxiety disorders in psychiatric inpatient settings.
Sponsor: Region Stockholm
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 16, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Depression, Anxiety Disorders
NCT01892124Source recordAI-normalized
Healthy Hearts, Healthy Minds
The 'Healthy Hearts, Healthy Minds' study, sponsored by the University of Washington, targets a critical health issue among American Indians in the Northwest, specifically addressing the intersection of cardiovascular disease (CVD), diabetes, and depression. Given the high prevalence of these conditions in this demographic, the intervention's culturally adapted approach may offer a unique market opportunity for behavioral health solutions tailored to indigenous populations. If the pilot shows efficacy, it could lead to a larger-scale randomized controlled trial (RCT) and potential partnerships with health organizations and governmental bodies focused on minority health disparities. The findings could also inform future product development in behavioral health interventions, particularly those integrating motivational interviewing and cognitive-behavioral therapy (CBT).
AI analysis
Indication: Cardiovascular Diseases
Modality: behavioral intervention
Target: Cognitive-behavioral mechanisms and motivational interviewing techniques aimed at reducing depressive symptoms and cardiovascular disease risk factors.
Sponsor: University of Washington
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 15, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Depression
NCT06078124Source recordAI-normalized
Sibling-Support for Adolescent Girls (SSAGE): A Whole-family, Gender Transformative Approach to Preventing Mental Illness Among Forcibly Displaced Adolescent Girls
The SSAGE trial, sponsored by Washington University School of Medicine, addresses a critical gap in mental health interventions for forcibly displaced adolescent girls, particularly in the context of Colombia. This innovative approach leverages a whole-family model to enhance mental health outcomes, focusing on gender equity and family dynamics. The potential for scalability in humanitarian settings presents a unique market opportunity, especially given the rising global displacement crisis. The findings could influence policy and funding for mental health programs targeting vulnerable populations, thereby enhancing the competitive landscape for organizations involved in mental health and humanitarian aid. Stakeholders should consider the implications of successful outcomes on future funding and partnerships in mental health interventions.
AI analysis
Indication: Anxiety
Modality: behavioral intervention
Target: Gender transformative family intervention aimed at preventing mental illness among forcibly displaced adolescent girls.
Sponsor: Washington University School of Medicine
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 14, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Depression
NCT07429357Source recordAI-normalized
Research on Education With Individualized REwarding Behaviour (REWIRE): A Comparison of Two Youth Mental Health Programs
The REWIRE study, sponsored by Gary Goldfield at the Children's Hospital of Eastern Ontario, aims to evaluate a novel behavioral intervention targeting social media use in adolescents aged 12-17 with anxiety and depression. Given the increasing prevalence of mental health issues among youth and the growing concern over social media's impact, this intervention addresses a significant market need. If successful, REWIRE could provide a scalable, low-cost solution within youth mental health care frameworks, particularly relevant in contexts where traditional services are limited. The competitive landscape includes existing mental health programs, but REWIRE's focus on objective monitoring and family engagement may differentiate it. Diligence should focus on feasibility, adherence rates, and potential for integration into existing healthcare systems.
AI analysis
Indication: Anxiety Depression
Modality: behavioral intervention
Target: Behavioral modification of social media use and reinforcement of alternative non-screen activities in adolescents experiencing anxiety and depression.
Sponsor: Gary Goldfield
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 11, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Anxiety Depression
NCT06365645Source recordAI-normalized
Examining the Feasibility and Acceptability of a Novel App-based Cognitive Behavioral Therapy Intervention for Preventing Postpartum Depression
The M.Bapp study, sponsored by Women and Infants Hospital of Rhode Island, aims to assess the feasibility and acceptability of a novel app-based intervention designed to prevent postpartum depression (PPD) among high-risk mothers. Given that PPD affects 10-25% of mothers, particularly those with personal or obstetric risk factors, there is a significant market opportunity for effective digital health solutions in maternal mental health. The adaptation of the Mothers & Babies Program into an app format could enhance accessibility and engagement, potentially positioning M.Bapp as a leading digital intervention in this space. The study's outcomes may inform future commercialization strategies and partnerships, particularly in the context of increasing demand for digital health solutions in maternal care.
AI analysis
Indication: Postpartum Depression
Modality: behavioral intervention
Target: Cognitive Behavioral Therapy (CBT) intervention for postpartum depression prevention.
Sponsor: Women and Infants Hospital of Rhode Island
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 08, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Postpartum Depression
NCT03452670Source recordAI-normalized
Contemplative Well-being Apps for the Workplace
The study, sponsored by Emory University, investigates the efficacy of a meditation app aimed at enhancing well-being among adult workforce populations under significant time constraints. Given the increasing prevalence of mental health issues in the workplace, this asset addresses a growing market need for accessible mental health solutions. The competitive landscape includes various mindfulness and wellness apps, but this study's focus on biomarker analysis and neural function may provide unique insights that could differentiate the app in a crowded market. The results could inform potential partnerships with corporations seeking to improve employee well-being and productivity, as well as opportunities for commercialization of the app itself.
AI analysis
Indication: Social Behavior
Modality: behavioral intervention
Target: Contemplative practices delivered via smartphone applications, focusing on mindfulness and meditation to improve well-being and reduce stress in workplace settings.
Sponsor: Emory University
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 03, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Depression
NCT05127369Source recordAI-normalized
Safety and Efficacy of Dental Pulp Mesenchymal Cells in the Treatment of Depression:
The clinical trial sponsored by CAR-T (Shanghai) Biotechnology Co., Ltd. aims to evaluate the safety and efficacy of dental pulp mesenchymal cell injections in treating severe depressive disorder. Given the increasing prevalence of depression globally and the limitations of current antidepressant therapies, this innovative approach could position CAR-T as a pioneer in the regenerative medicine space for mental health. The trial's design includes a positive control (fluoxetine), which may enhance credibility but also introduces competition from established antidepressants. The market for depression treatments is substantial, with a growing demand for novel therapies, particularly those that address treatment-resistant cases. Successful outcomes could lead to significant commercial opportunities, including partnerships, licensing, and potential market exclusivity, depending on the regulatory landscape and patent protections.
AI analysis
Indication: Depression
Modality: small molecule
Target: Dental pulp mesenchymal cells (DPMCs) as a regenerative therapy for severe depressive disorder.
Sponsor: CAR-T (Shanghai) Biotechnology Co., Ltd.
Source URL: ClinicalTrials.gov
Source updated: Detailed source ingestion pending
Ingested: Jul 03, 2026
Model: trialsignal-ai-v1
Validation: validated
Matched by conditions: Depression