Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic Aim 1 of Rare Diseases Clinical Research Network (RDCRN) Project 2 is a PHASE1 clinical asset sponsored by Vanderbilt University in Multiple System Atrophy, Orthostatic Hypotension, Supine Hypertension. SEO and diligence focus: Trimethaphan, Placebo, endpoint relevance, enrollment feasibility, competitive positioning, readout timing and IP durability.