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Phase I Study to Evaluate Cellular Immunotherapy Using Memory-Enriched T Cells Lentivirally Transduced to Express a CS1-Targeting, Hinge-Optimized, 41BB-Costimulatory Chimeric Antigen Receptor and a Truncated EGFR Following Lymphodepleting Chemotherapy in Adult Patients With CS1+ Multiple Myeloma
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT03710421-Jul 28, 2026
NCT ID
NCT03710421
Status
SUSPENDED
Phase
Phase 1
Sponsor
City of Hope Medical Center
Executive brief
Investment-Ready Snapshot
The CS1-CAR T therapy is positioned within the competitive landscape of advanced therapies for relapsed or refractory multiple myeloma, a market projected to grow significantly due to increasing incidence rates and the need for effective treatment options. The trial, sponsored by City of Hope Medical Center, aims to establish safety and dosing parameters, which are critical for subsequent phases and potential commercialization. The suspension of the trial due to slow accrual raises concerns about patient recruitment strategies and may impact timelines for market entry. The collaboration with the National Cancer Institute (NCI) could enhance credibility and provide additional resources for future development. The success of this therapy could position City of Hope as a leader in CAR T-cell therapies, particularly in the niche of CS1-positive multiple myeloma.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT03710421
Indication
Recurrent Plasma Cell Myeloma
Modality
small molecule
Target
CS1 (also known as SLAMF7), a surface protein expressed on multiple myeloma cells, targeted by a chimeric antigen receptor (CAR) engineered in T cells.
Intervention
CS1-CAR T Therapy, Cyclophosphamide, Fludarabine, Leukapheresis
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.