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Clinical trial intelligence report
A Multiple Center Study on NOXA Expression-guided Randomized Chidamide Bridging Intervention in CAR-T Treated NHL Patients
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT05370547-Jul 28, 2026
NCT ID
NCT05370547
Status
UNKNOWN
Phase
Phase 1/2
Sponsor
Chinese PLA General Hospital
Executive brief
Investment-Ready Snapshot
This clinical trial, sponsored by the Chinese PLA General Hospital, aims to evaluate the efficacy and safety of chidamide as a bridging therapy in CAR-T treated patients with recurrent or refractory B-cell NHL. The study targets a significant unmet need in the oncology market, particularly for patients exhibiting low NOXA expression, which is associated with CAR-T resistance. The competitive landscape includes existing CAR-T therapies, but the integration of chidamide may provide a differentiated approach to enhance treatment outcomes. Given the increasing prevalence of NHL and the growing adoption of CAR-T therapies, successful results could position the sponsor favorably within the expanding biopharmaceutical market focused on hematologic malignancies.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT05370547
Indication
Non Hodgkin's Lymphoma
Modality
small molecule
Target
NOXA protein expression modulation via histone deacetylase inhibition (HDACi) to enhance CAR-T cell efficacy in B-cell non-Hodgkin's lymphoma (NHL).
Intervention
Chidamide, Fludarabine and cyclophosphamide, Anti-CD19 CAR-T cells
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.