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A Multi-Center, Prospective, Single-Arm, Phase 2 Clinical Study on the Efficacy and Safety of Lisafotoclax Combined With Decitabine and Homoharringtonine in Patients With Acute Myeloid Leukemia Previously Treated With Venetoclax Combined With Azacitidine Regimen
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT07505160-Jul 28, 2026
NCT ID
NCT07505160
Status
NOT_YET_RECRUITING
Phase
Phase 2
Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Executive brief
Investment-Ready Snapshot
This Phase 2 clinical trial is positioned to evaluate a novel combination therapy for AML patients who have previously failed or are intolerant to the Venetoclax plus Azacitidine regimen. The target patient population is significant, given the high unmet medical need in relapsed/refractory AML. If successful, this combination could provide a competitive edge in a market dominated by limited treatment options for this patient demographic. The trial's location in China may also offer strategic advantages in terms of regulatory pathways and market entry, particularly in the Asia-Pacific region, which is experiencing rapid growth in oncology therapeutics. Companies should monitor the trial's progress closely for potential partnership or acquisition opportunities, especially if the results demonstrate a favorable safety and efficacy profile.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT07505160
Indication
Acute Myeloid Leukemia (AML)
Modality
small molecule
Target
BCL-2 inhibition via Lisafotoclax, combined with Decitabine (a hypomethylating agent) and Homoharringtonine (an alkaloid anti-leukemia agent), targeting acute myeloid leukemia (AML) pathways.
Intervention
Lisafotoclax, Decitabine, Homoharringtonine
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.