TrialSignal
Clinical trial intelligence report
Phase 3 Study to Compare the Efficacy and Safety of Masitinib in Combination With Riluzole Versus Placebo in Combination With Riluzole in the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT03127267-Jul 28, 2026
NCT ID
NCT03127267
Status
RECRUITING
Phase
Phase 3
Sponsor
AB Science
Executive brief
Investment-Ready Snapshot
AB Science is currently conducting a Phase 3 clinical trial to evaluate the efficacy and safety of masitinib in combination with riluzole for the treatment of ALS. The market for ALS therapies is competitive, with riluzole being the current standard of care. If successful, masitinib could provide a novel therapeutic option that enhances the effects of riluzole, potentially capturing a significant share of the ALS treatment market. The trial is actively recruiting across multiple international sites, indicating robust interest and investment in this therapeutic area. The outcome of this trial could influence AB Science's market positioning and valuation significantly, especially if the results demonstrate a statistically significant improvement in ALSFRS-R scores compared to placebo.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT03127267
Indication
Amyotrophic Lateral Sclerosis
Modality
small molecule
Target
Masitinib targets mast cells and microglia, functioning as a selective oral tyrosine kinase inhibitor with neuroprotective capabilities, aiming to modulate neuroinflammation in ALS.
Intervention
Masitinib (6.0), Riluzole, Placebo, Masitinib (4.5)
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.