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The Effect of ß-cell Specific Glucokinase Mutation on Glucose Homeostasis and Insulin Secretion in a MODY-2 Family
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT01960231-Jul 28, 2026
NCT ID
NCT01960231
Status
UNKNOWN
Phase
Observational
Sponsor
Sheba Medical Center
Executive brief
Investment-Ready Snapshot
The study focuses on the role of glucokinase mutations in MODY-2 diabetes, a rare genetic form of diabetes that affects insulin secretion and glucose metabolism. Given the increasing prevalence of diabetes globally, insights from this study could lead to novel therapeutic strategies targeting glucokinase pathways. The findings may enhance understanding of diabetes mechanisms, potentially influencing drug development in the diabetes market. Competitive implications include the potential for new diagnostics or therapeutics that could differentiate from existing diabetes treatments, particularly for genetically defined patient populations. Diligence considerations should include assessing the commercial viability of targeting glucokinase mutations and the potential for partnerships with genetic testing companies.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT01960231
Indication
MODY-2 Diabetes
Modality
RNA therapy
Target
Glucokinase (Hexokinase IV), specifically mutations in the glucokinase promoter affecting pancreatic beta-cell function.
Intervention
OGTT
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.