This clinical trial, sponsored by The First Affiliated Hospital of Soochow University, aims to address alloimmune-mediated platelet transfusion refractoriness (PTR) in patients with acute leukemia in complete remission. The market for therapies targeting PTR is significant, given the high incidence of this condition in acute leukemia patients, particularly during the myelosuppression period post-chemotherapy. Current management strategies have proven largely unsatisfactory, creating an opportunity for innovative therapies like CAR-T cell treatments. The involvement of multiple collaborating hospitals and a biotech company indicates a robust support network, which may enhance the trial's credibility and potential for commercialization. If successful, this therapy could capture a niche market within hematology, particularly among patients who are refractory to existing treatments.