TrialSignal
Clinical trial intelligence report
A Randomized, Double-Blind, Placebo-Controlled Study of Safety and Efficacy of Botulinum Toxin Type B (Myobloc) in Sialorrhea in Amyotrophic Lateral Sclerosis
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT00125203-Jul 28, 2026
NCT ID
NCT00125203
Status
COMPLETED
Phase
Phase 2/3
Sponsor
The University of Texas Health Science Center at San Antonio
Executive brief
Investment-Ready Snapshot
The study evaluates Myobloc's efficacy in treating sialorrhea in ALS patients, a condition with limited treatment options. If successful, this could position Myobloc as a preferred therapy in a niche market, potentially expanding its use beyond existing indications. The ALS market is characterized by high unmet needs, and successful outcomes could lead to increased adoption and market share. Competitive landscape includes other botulinum toxin products and anticholinergic medications, but Myobloc's unique mechanism may offer advantages in refractory cases. Diligence should focus on the safety profile and long-term effects, as well as potential regulatory hurdles for expanded indications.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT00125203
Indication
Amyotrophic Lateral Sclerosis
Modality
small molecule
Target
Botulinum toxin type B (Myobloc) targets the neuromuscular junction to inhibit acetylcholine release, thereby reducing muscle activity and secretions, specifically in the salivary glands.
Intervention
Botulinum toxin type B (Myobloc), Injection of salivary glands
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.