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An Exploratory Basket Study on The Application of Therapeutic mRNA Vaccine Targeting FAP in Advanced Malignant Solid Tumors
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT07363369-Jul 28, 2026
NCT ID
NCT07363369
Status
NOT_YET_RECRUITING
Phase
Phase 1
Sponsor
West China Hospital
Executive brief
Investment-Ready Snapshot
The exploratory basket study sponsored by West China Hospital aims to evaluate the safety and efficacy of a therapeutic mRNA vaccine targeting FAP in combination with immune checkpoint inhibitors for patients with advanced malignant solid tumors. Given the increasing interest in mRNA-based therapies and the critical role of CAFs in tumor progression, this trial could position the sponsor favorably within the oncology market. The potential to enhance the efficacy of existing immunotherapies by targeting the tumor microenvironment may provide a competitive edge against other therapies that do not address CAFs. However, the trial is not yet recruiting, and the timeline for results will be crucial for market positioning and investor interest.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT07363369
Indication
Advanced Malignant Solid Tumors
Modality
RNA therapy
Target
Fibroblast Activation Protein (FAP), a therapeutic target for cancer-associated fibroblasts (CAFs) in the tumor microenvironment.
Intervention
FAP mRNA vaccine (dose 1) + immune checkpoint inhibitors, FAP mRNA vaccine (dose 2) + immune checkpoint inhibitors, FAP mRNA vaccine (dose 3) + immune checkpoint inhibitors, FAP mRNA vaccine (dose 4) + immune checkpoint inhibitors
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
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Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
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Contacts
Detailed source ingestion pending.