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Clinical trial intelligence report
A Double-Blind, Placebo-Controlled, Randomised, 4-Week Safety and Tolerability Study of TRx0237 in Subjects With Mild to Moderate Alzheimer's Disease on Pre-Existing Stable Acetylcholinesterase Inhibitor and/or Memantine Therapy
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT01626391-Jul 28, 2026
NCT ID
NCT01626391
Status
TERMINATED
Phase
Phase 2
Sponsor
TauRx Therapeutics Ltd
Executive brief
Investment-Ready Snapshot
TRx0237, developed by TauRx Therapeutics, aims to address the unmet need in Alzheimer's disease treatment, particularly for patients already on acetylcholinesterase inhibitors and/or memantine. The market for Alzheimer's therapeutics is significant, with increasing prevalence and limited effective options. The termination of this study for administrative reasons raises concerns about the asset's viability and may impact investor confidence. Competitive analysis indicates that while there are several players in the Alzheimer's space, TRx0237's unique mechanism targeting tau pathology could differentiate it if safety and efficacy are established.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT01626391
Indication
Alzheimer's Disease
Modality
small molecule
Target
Methylthioninium (TRx0237) is a synthetic derivative of phenothiazine, targeting tau aggregation in Alzheimer's disease.
Intervention
TRx0237, Placebo
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.