TrialSignal
Clinical trial intelligence report
ELR+CXCL Cytokines in Metastatic Kidney Cancers: Predictive Markers of Resistance to Sunitinib and New Relevant Therapeutic Targets in Refractory Patients
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT03097601-Jul 28, 2026
NCT ID
NCT03097601
Status
COMPLETED
Phase
Completed (Observational Study)
Sponsor
Centre Antoine Lacassagne
Executive brief
Investment-Ready Snapshot
The study conducted by Centre Antoine Lacassagne aims to identify predictive markers of resistance to sunitinib in mRCC patients, focusing on ELR+CXCL cytokines as potential therapeutic targets. Given the high unmet need for effective treatments in mRCC, the identification of these biomarkers could lead to improved patient stratification and treatment personalization, enhancing market opportunities for diagnostics and targeted therapies. The competitive landscape includes existing anti-angiogenic therapies and emerging immunotherapies. Companies developing companion diagnostics for mRCC may find strategic partnerships or acquisition opportunities in this space, particularly if the findings validate the clinical utility of ELR+CXCL cytokines.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT03097601
Indication
Metastatic Kidney Cancers
Modality
RNA therapy
Target
ELR+CXCL cytokines (specifically CXCL1, CXCL5, CXCL7, CXCL8) and their receptors (CXCR1, CXCR2) involved in pro-inflammatory and pro-angiogenic signaling pathways in metastatic renal cell carcinoma (mRCC).
Intervention
ELR+CXCL cytokines levels are of sunitinib response
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.