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Clinical trial intelligence report
A Safety and Tolerability Study of Mexiletine in Patients With Sporadic Amyotrophic Lateral Sclerosis (SALS)
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT01849770-Jul 28, 2026
NCT ID
NCT01849770
Status
COMPLETED
Phase
Phase 2
Sponsor
University of Washington
Executive brief
Investment-Ready Snapshot
The clinical trial for mexiletine in patients with sporadic Amyotrophic Lateral Sclerosis (SALS) aims to evaluate the safety and efficacy of two dosing regimens (300 mg and 900 mg) compared to a placebo. Given the lack of effective treatments for ALS, a successful outcome could position mexiletine as a novel therapeutic option in a market with significant unmet needs. The ALS market is characterized by limited competition, primarily dominated by riluzole and edaravone, which may provide a favorable environment for mexiletine if proven effective. The trial's completion and subsequent data could attract interest from larger pharmaceutical companies for potential partnerships or acquisitions, enhancing the asset's commercial viability.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT01849770
Indication
Sporadic Amyotrophic Lateral Sclerosis
Modality
small molecule
Target
Sodium channels (specifically, use-dependent sodium channel blockade)
Intervention
Mexiletine, Placebo
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.