TrialSignal
Clinical trial intelligence report
Immunoregulation by Controlled Parasite Exposure in Multiple Sclerosis.
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT00630383-Jul 28, 2026
NCT ID
NCT00630383
Status
WITHDRAWN
Phase
Phase 2
Sponsor
University of Nottingham
Executive brief
Investment-Ready Snapshot
The study, sponsored by the University of Nottingham, explores the therapeutic potential of controlled hookworm exposure as a novel immunomodulatory treatment for relapsing forms of Multiple Sclerosis (MS). Given the increasing prevalence of MS in Western populations and the limitations of current disease-modifying therapies, this approach could address an unmet medical need. The market for MS therapies is substantial, with existing treatments generating billions in revenue. However, the unique mechanism of action involving parasitic infection may face regulatory scrutiny and public perception challenges. Competitive analysis indicates that while there are numerous MS therapies, few explore immunomodulation through parasitic mechanisms, potentially positioning this study as a pioneering effort in a niche market. Diligence considerations should focus on safety, tolerability, and the ethical implications of using live parasites in treatment.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT00630383
Indication
Multiple Sclerosis
Modality
protein therapy
Target
CD4+CD25+foxp3+ regulatory T cells and associated immune modulation pathways.
Intervention
Live Hookworm Larvae, Histamine
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.