TrialSignal
Clinical trial intelligence report
Cabozantinib (XL184) With Panitumumab in Subjects With KRAS Wild-Type Metastatic Colorectal Cancer and Cabozantinib Monotherapy in Subjects With MET Amplified Treatment-Refractory Colorectal Cancer
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT02008383-Jul 28, 2026
NCT ID
NCT02008383
Status
COMPLETED
Phase
Phase 1
Sponsor
John Strickler, M.D.
Executive brief
Investment-Ready Snapshot
The trial evaluates the combination of cabozantinib and panitumumab in KRAS wild-type metastatic colorectal cancer (CRC) and cabozantinib monotherapy in MET amplified CRC. Given the high unmet need in treatment-refractory CRC, successful outcomes could position this combination as a competitive option in the oncology market. The trial's completion in 2018 suggests that data may be available for further analysis, which could influence strategic partnerships or acquisitions in the oncology space. The involvement of Exelixis indicates potential commercial interest in the cabozantinib franchise, which could enhance market positioning if results are favorable.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT02008383
Indication
Colorectal Cancer
Modality
protein therapy
Target
MET gene amplification and EGFR signaling pathway (targeted by panitumumab)
Intervention
Panitumumab, Cabozantinib
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.