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A Phase 1, Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-6231, Encoding for a Human Serum Albumin - Interleukin-2 Mutein Fusion Protein (HSA-IL2m), in Healthy Adults
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT04916431-Jul 28, 2026
NCT ID
NCT04916431
Status
COMPLETED
Phase
Phase 1
Sponsor
ModernaTX, Inc.
Executive brief
Investment-Ready Snapshot
ModernaTX, Inc. is advancing mRNA-6231, an innovative therapeutic candidate targeting the immune modulation space through a novel fusion protein approach. The Phase 1 trial, which has been completed, aims to establish safety and tolerability profiles for escalating doses of mRNA-6231 in healthy adults. Given the growing interest in mRNA-based therapies, particularly in oncology and autoimmune diseases, successful outcomes could position Moderna favorably against competitors in the immunotherapy landscape. The trial's completion and subsequent data analysis will be critical for informing potential partnerships or further development strategies, especially in light of the increasing demand for effective immunomodulatory agents.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT04916431
Indication
Healthy Volunteers
Modality
RNA therapy
Target
Human Serum Albumin - Interleukin-2 Mutein Fusion Protein (HSA-IL2m)
Intervention
mRNA-6231
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.