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Clinical trial intelligence report
A Single-center, Open-label, Single-arm Clinical Study of the Safety and Efficacy of KD-496 CAR-T Therapy in Advanced NKG2DL+/CLDN18.2+ Solid Tumors
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT05583201-Jul 28, 2026
NCT ID
NCT05583201
Status
UNKNOWN
Phase
Phase 1
Sponsor
jianming xu
Executive brief
Investment-Ready Snapshot
The KD-496 CAR-T therapy targets advanced solid tumors expressing NKG2DL and CLDN18.2, specifically gastric and pancreatic cancers. Given the limited treatment options for patients who have failed standard therapies, this asset addresses a significant unmet need in oncology. The competitive landscape includes other CAR-T therapies and emerging treatments targeting similar tumor antigens. Successful outcomes could position KD-496 favorably in a niche market, potentially leading to partnerships or acquisition interest from larger biopharma companies. Diligence should focus on regulatory pathways, manufacturing scalability, and the evolving landscape of CAR-T therapies in solid tumors.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT05583201
Indication
Gastric Cancer
Modality
gene therapy
Target
NKG2D/CLDN18.2
Intervention
KD-496
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.