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Prospective, Multicenter, Open, One-arm Clinical Study of the Safety and Efficacy of the R/R B-NHL Regimen With BTK Inhibitor+Anti-CD19 CAR-T Cells
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT05744037-Jul 28, 2026
NCT ID
NCT05744037
Status
UNKNOWN
Phase
Phase 2
Sponsor
The Affiliated Hospital of Xuzhou Medical University
Executive brief
Investment-Ready Snapshot
The clinical trial is sponsored by The Affiliated Hospital of Xuzhou Medical University and aims to evaluate the safety and efficacy of a combination regimen of BTK inhibitors and Anti-CD19 CAR-T cells in patients with relapsed/refractory B-cell Non-Hodgkin Lymphoma (B-NHL). Given the increasing prevalence of B-NHL and the limitations of current treatment options, this study addresses a significant unmet medical need. If successful, the results could position the combination therapy as a competitive option in the oncology market, particularly against existing therapies such as monoclonal antibodies and other CAR-T cell therapies. The trial's outcomes may also influence market dynamics and investor interest in CAR-T and BTK inhibitor technologies.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT05744037
Indication
B-cell Non Hodgkin Lymphoma
Modality
protein therapy
Target
CD19 (targeted by Anti-CD19 CAR-T cells) and BTK (Bruton's Tyrosine Kinase, inhibited by BTK inhibitors such as Ibrutinib)
Intervention
regimen with BTK inhibitor +Anti-CD19 CAR T cells
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.