TrialSignal
Clinical trial intelligence report
Phase I Trial of G Protein-coupled Receptor Class C Group 5 Member D (GPRC5D) Targeted MCARH109 Chimeric Antigen Receptor (CAR) Modified T Cells for the Treatment of Multiple Myeloma
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT04555551-Jul 28, 2026
NCT ID
NCT04555551
Status
ACTIVE_NOT_RECRUITING
Phase
Phase 1
Sponsor
Memorial Sloan Kettering Cancer Center
Executive brief
Investment-Ready Snapshot
The Phase I trial of MCARH109 CAR T-cell therapy, targeting GPRC5D for relapsed or refractory multiple myeloma, is sponsored by Memorial Sloan Kettering Cancer Center. Given the high unmet need in multiple myeloma, particularly among patients who have undergone multiple lines of therapy, this asset could capture significant market share if proven safe and effective. The competitive landscape includes existing CAR T-cell therapies targeting BCMA and other antigens, but GPRC5D represents a novel target that may provide therapeutic advantages. The trial's focus on safety and dose escalation will be critical for future development and potential commercialization. Investors should monitor the trial's progress and outcomes closely, as successful results could lead to partnerships or acquisition interest from larger biopharma companies.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT04555551
Indication
Multiple Myeloma
Modality
protein therapy
Target
G Protein-coupled Receptor Class C Group 5 Member D (GPRC5D)
Intervention
Infusion of MCARH109 T cells
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.