TrialSignal
Clinical trial intelligence report
Phase II/III, Multicenter, Randomized, Parallel Group, Double-blind, Placebo Controlled Study to Assess Safety and Efficacy of TRO19622 in Amyotrophic Lateral Sclerosis (ALS) Patients Treated With Riluzole
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT00868166-Jul 28, 2026
NCT ID
NCT00868166
Status
COMPLETED
Phase
Phase 2/3
Sponsor
Hoffmann-La Roche
Executive brief
Investment-Ready Snapshot
TRO19622, developed by Hoffmann-La Roche, is positioned as an add-on therapy to the existing ALS treatment, Riluzole. The ALS market is characterized by limited treatment options, with Riluzole being the only approved drug that has shown a modest effect on survival. The success of TRO19622 could provide a significant competitive advantage, addressing a critical unmet need in ALS therapy. The trial's completion and subsequent results may enhance Roche's portfolio in neurology, potentially leading to market exclusivity if the product demonstrates efficacy and safety. Given the high incidence of ALS and the increasing focus on neurodegenerative diseases, the commercial prospects appear promising, contingent upon positive trial outcomes.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT00868166
Indication
Amyotrophic Lateral Sclerosis
Modality
small molecule
Target
TRO19622 (Olesoxime) is a small molecule designed to modulate mitochondrial function and neuroprotection, potentially targeting pathways involved in neuronal survival and degeneration in Amyotrophic Lateral Sclerosis (ALS).
Intervention
Olesoxime, Placebo Comparator, Riluzole
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.