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Clinical trial intelligence report
Pharmacodynamics, Pharmacogenomics, and Preliminary Safety and Efficacy of Alemtuzumab Induction and Tacrolimus in Pediatric Intestinal Transplantation (IND # 100496)
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT01208337-Jul 28, 2026
NCT ID
NCT01208337
Status
COMPLETED
Phase
Phase 2
Sponsor
University of Pittsburgh
Executive brief
Investment-Ready Snapshot
The clinical trial evaluating Alemtuzumab in pediatric intestinal transplantation presents a significant opportunity in the transplant market, particularly for pediatric patients who face high rates of acute cellular rejection and complications post-transplant. The use of Alemtuzumab, a monoclonal antibody targeting CD52, could potentially reduce the need for long-term steroid use and improve patient outcomes. Given the limited options for immunosuppression in this demographic, successful results could position Alemtuzumab favorably against existing therapies, enhancing its market potential. However, the risk of post-transplant lymphoproliferative disorder (PTLD) and opportunistic infections must be carefully managed to ensure competitive viability. Stakeholders should consider the implications of these findings on market access and reimbursement strategies.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT01208337
Indication
Evidence of Liver Transplantation
Modality
monoclonal antibody
Target
CD52 antigen
Intervention
Alemtuzumab
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.