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An Exploratory Clinical Study to Evaluate the Safety and Efficacy of BZE2204 CD19/CD22/BCMA CAR-T Cells in Subjects With Relapsed or Refractory Active Autoimmune Diseases
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT07174843-Jul 28, 2026
NCT ID
NCT07174843
Status
RECRUITING
Phase
Phase 1
Sponsor
Shanghai Cell Therapy Group Co.,Ltd
Executive brief
Investment-Ready Snapshot
BZE2204 represents a novel CAR-T cell therapy targeting multiple antigens (CD19, CD22, and BCMA) for the treatment of relapsed or refractory autoimmune diseases, specifically idiopathic inflammatory myopathies (IIM), immune thrombocytopenia (ITP), and systemic lupus erythematosus (SLE). The market for autoimmune therapies is significant, with increasing demand for innovative treatments due to the limitations of current therapies. The competitive landscape includes other CAR-T therapies and biologics targeting similar conditions, but BZE2204's tri-target approach may provide a unique selling proposition. The trial is currently recruiting, with anticipated completion in late 2027, suggesting a potential market entry around 2028, contingent on successful outcomes. Diligence should focus on safety and efficacy data, as well as regulatory pathways in China and potentially other markets.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT07174843
Indication
Idiopathic Inflammatory Myopathies(IIM)
Modality
cell therapy
Target
CD19, CD22, BCMA (B-cell maturation antigen)
Intervention
CD19/CD22/BCMA CAR-T cells(BZE2204)
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.