TrialSignal
Clinical trial intelligence report
A Phase I/Ib Open-label, Multi-center, Dose Escalation Study of GWN323 (Anti-GITR) as a Single Agent and in Combination With PDR001 (Anti-PD-1) in Patients With Advanced Solid Tumors and Lymphomas
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 03, 2026
Report code
NCT02740270-Jul 03, 2026
NCT ID
NCT02740270
Status
COMPLETED
Phase
Phase 1/Ib
Sponsor
Novartis Pharmaceuticals
Executive brief
Investment-Ready Snapshot
The Phase I/Ib study of GWN323 (anti-GITR) in combination with PDR001 (anti-PD-1) represents a strategic initiative by Novartis Pharmaceuticals to enhance the therapeutic landscape for patients with advanced solid tumors and lymphomas. Given the increasing interest in immuno-oncology therapies, this dual-target approach may provide a competitive edge in a crowded market. The trial's completion and subsequent data analysis will be critical in determining the viability of GWN323 as a standalone treatment and in combination therapy, potentially positioning Novartis favorably against competitors in the immunotherapy space. The enrollment of approximately 264 patients indicates a significant investment in understanding the safety and efficacy of these agents, which could lead to future regulatory submissions and market entry.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT02740270
Indication
Solid Tumors
Modality
small molecule
Target
GITR (Glucocorticoid-Induced TNFR-Related Protein) and PD-1 (Programmed Cell Death Protein 1)
Intervention
GWN323, PDR001
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.