This observational study, sponsored by the Medical University of Warsaw, aims to elucidate the role of rare metals and trace elements in the pathophysiology of hip and knee osteoarthritis. The findings could lead to novel therapeutic strategies, such as supplementation or immunomodulation, enhancing treatment options for osteoarthritis patients. Given the increasing prevalence of osteoarthritis and the growing market for joint health therapies, successful outcomes may position the sponsor favorably within a competitive landscape that includes both pharmaceutical and nutraceutical interventions. The study's focus on biochemical and immunological parameters may also attract interest from companies involved in biomarker development and personalized medicine.