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A Single-Center, Prospective, Randomized Controlled Clinical Study of Oral Diammonium Glycyrrhizinate for Attenuating Toxicity and Enhancing Efficacy of CAR-T Cell Therapy
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jul 28, 2026
Report code
NCT07616271-Jul 28, 2026
NCT ID
NCT07616271
Status
NOT_YET_RECRUITING
Phase
Phase 2/3
Sponsor
Tongji Hospital
Executive brief
Investment-Ready Snapshot
This clinical trial, sponsored by Tongji Hospital, aims to evaluate the efficacy of oral diammonium glycyrrhizinate in enhancing the therapeutic outcomes of CAR-T cell therapy for patients with large B-cell lymphoma. The study addresses critical issues such as reducing the incidence and severity of CRS, a significant adverse effect associated with CAR-T therapies. If successful, this intervention could position diammonium glycyrrhizinate as a valuable adjunctive treatment in the CAR-T landscape, potentially expanding its market appeal and providing a competitive edge against existing supportive care options. The trial's outcomes may also influence future treatment protocols and reimbursement strategies, highlighting the need for diligence in assessing market entry and partnership opportunities.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT07616271
Indication
Patients With Large B-cell Lymphoma Receiving CAR-T Cell Therapy
Modality
cell therapy
Target
Oral diammonium glycyrrhizinate, targeting pyroptosis regulation and cytokine release syndrome (CRS) mitigation in CAR-T cell therapy.
Intervention
Diammonium glycyrrhizinate Capsules
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.