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Clinical trial intelligence report
Decitabine Followed by Donor Lymphocyte Infusion for Patients With Relapsed Acute Myeloblastic Leukemia(AML) After Allogeneic Stem Cell Transplantation
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 25, 2026
Report code
NCT01758367-Jun 25, 2026
NCT ID
NCT01758367
Status
UNKNOWN
Phase
Phase 1/2
Sponsor
Chinese PLA General Hospital
Executive brief
Investment-Ready Snapshot
The clinical trial is sponsored by the Chinese PLA General Hospital and focuses on the use of decitabine followed by donor lymphocyte infusion (DLI) in patients with relapsed acute myeloid leukemia (AML) post-allogeneic stem cell transplantation. Given the increasing incidence of AML and the limited treatment options available, this trial addresses a significant unmet medical need. The potential for decitabine to enhance the efficacy of adoptive T cell therapy could position it favorably in the competitive landscape of AML treatments. Market implications include potential partnerships or licensing opportunities for the sponsor, particularly if the trial demonstrates significant efficacy and safety. Diligence considerations should include the regulatory pathway for decitabine in this indication and the competitive profile of existing therapies.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT01758367
Indication
Recurrent Adult Acute Myeloid Leukemia
Modality
small molecule
Target
Decitabine (5-aza-2'-deoxycytidine) acts as a demethylating agent, targeting DNA methylation to up-regulate immune-associated proteins, including cancer testis antigens (CTA), major histocompatibility complex (MHC), and co-stimulatory molecules, while also inducing FOXP3 expression in CD4+ T cells.
Intervention
Deciatbine(DAC)
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.