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Clinical trial intelligence report
A Single-Arm, Open-Label Study to Evaluate Safety and Efficacy of B7H3 or HBsAg Targeting CAR-T in Treating Advanced Hepatocellular Carcinoma
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 25, 2026
Report code
NCT05323201-Jun 25, 2026
NCT ID
NCT05323201
Status
RECRUITING
Phase
Phase 1/2
Sponsor
The Affiliated Hospital of Xuzhou Medical University
Executive brief
Investment-Ready Snapshot
The study, sponsored by The Affiliated Hospital of Xuzhou Medical University, aims to evaluate the safety and efficacy of fhB7H3.CAR-T therapy in patients with advanced hepatocellular carcinoma. Given the high unmet medical need in HCC treatment and the increasing interest in CAR-T therapies, successful outcomes could position this therapy favorably within a competitive landscape that includes existing immunotherapies and emerging CAR-T products. The potential for a novel treatment option could attract interest from larger biopharma companies for partnerships or acquisition, particularly if early efficacy signals are observed. The estimated completion date in 2027 allows for a strategic timeline for market entry, assuming positive results.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT05323201
Indication
Hepatocellular Carcinoma
Modality
cell therapy
Target
B7H3 (B7 homolog 3), a protein highly expressed in hepatocellular carcinoma (HCC) cells, targeted by fully human CAR-T cells (fhB7H3.CAR-Ts).
Intervention
fhB7H3.CAR-Ts, Fludarabine, Cyclophosphamide
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.