TrialSignal
Clinical trial intelligence report
Allogeneic Natural Killer T-Cells Expressing CD19 Specific Chimeric Antigen Receptor and Interleukin-15 in Relapsed or Refractory B-Cell Malignancies
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 25, 2026
Report code
NCT03774654-Jun 25, 2026
NCT ID
NCT03774654
Status
ACTIVE_NOT_RECRUITING
Phase
Phase 1
Sponsor
Baylor College of Medicine
Executive brief
Investment-Ready Snapshot
The ANCHOR trial, sponsored by Baylor College of Medicine, targets relapsed or refractory B-cell malignancies, a significant unmet medical need with limited treatment options. The combination of CAR technology with NKT cells and IL-15 aims to enhance therapeutic efficacy and patient outcomes. Given the increasing interest in CAR therapies, particularly in hematological cancers, successful results could position this therapy competitively against existing CAR-T therapies, such as those targeting CD19. The trial's focus on a unique cell type (NKT cells) may provide a novel approach that could differentiate it in the market. The potential for long-term follow-up (up to 15 years) may also appeal to investors and stakeholders concerned with safety and efficacy over time.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT03774654
Indication
Refractory B-Cell Non-Hodgkin Lymphoma
Modality
gene therapy
Target
CD19 specific chimeric antigen receptor (CAR) on allogeneic Natural Killer T-cells (NKT cells) enhanced with Interleukin-15 (IL-15) and CD28 co-stimulation.
Intervention
CD19.CAR-aNKT cells
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.