TrialSignal
Clinical trial intelligence report
Phase Ib/II of the Combination of Fludarabine, Cytarabine, Idarubicin, G-CSF (FLAG-Ida) With Venetoclax and Asciminib in Patients With Advanced Phase Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Myeloid Leukemia
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 24, 2026
Report code
NCT07604233-Jun 24, 2026
NCT ID
NCT07604233
Status
NOT_YET_RECRUITING
Phase
Phase 1/2
Sponsor
M.D. Anderson Cancer Center
Executive brief
Investment-Ready Snapshot
The clinical trial, sponsored by M.D. Anderson Cancer Center, aims to evaluate the safety and efficacy of a novel combination therapy involving FLAG-Ida, venetoclax, and asciminib in patients with advanced CML and Ph+ AML. Given the increasing prevalence of these hematological malignancies and the limitations of current treatment options, successful outcomes could position this combination as a competitive therapeutic alternative in a market characterized by high unmet medical need. The trial's focus on patients who are newly diagnosed or relapsed/refractory suggests a strategic approach to capture a significant patient population. Furthermore, the involvement of a prestigious institution like M.D. Anderson enhances credibility and may facilitate future partnerships or licensing opportunities. However, the trial is not yet recruiting, and the timeline for results extends to 2033, which may impact investor interest in the short term.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT07604233
Indication
Myeloid Leukemia
Modality
small molecule
Target
BCR::ABL1 fusion protein and associated signaling pathways in chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute myeloid leukemia (Ph+ AML).
Intervention
Fludarabine, Cytarabine, Idarubicin, Filgrastim, Venetoclax, Asciminib, Blinatumomab
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.