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Clinical trial intelligence report
A Phase I/II Study of Lenalidomide Maintenance After Autologous Stem Cell Transplant for Elderly Patients With Acute Myeloid Leukemia (AML)
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 24, 2026
Report code
NCT02038153-Jun 24, 2026
NCT ID
NCT02038153
Status
TERMINATED
Phase
Phase 1/2
Sponsor
Albert Einstein College of Medicine
Executive brief
Investment-Ready Snapshot
The trial, sponsored by Albert Einstein College of Medicine, aimed to evaluate the safety and efficacy of lenalidomide as a maintenance therapy for elderly patients with acute myeloid leukemia (AML) post-autologous stem cell transplant. However, the study was terminated due to low patient accrual, indicating potential challenges in patient recruitment for this demographic. The market for AML therapies is competitive, with several established treatments and emerging therapies. The failure to complete this trial may impact the sponsor's position in the AML treatment landscape and could influence future investment decisions or collaborations in this area.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT02038153
Indication
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Modality
small molecule
Target
Lenalidomide targets the cereblon (CRBN) E3 ubiquitin ligase complex, leading to the degradation of specific transcription factors that promote tumor growth and survival, thereby enhancing immune response against cancer cells.
Intervention
Laboratory Biomarker Analysis, Lenalidomide
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.