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A Phase 1 Single Arm, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MT027 in Patients with Pleural Malignant Tumors
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 24, 2026
Report code
NCT06726564-Jun 24, 2026
NCT ID
NCT06726564
Status
RECRUITING
Phase
Phase 1
Sponsor
Suzhou Maximum Bio-tech Co., Ltd.
Executive brief
Investment-Ready Snapshot
MT027 is being developed by Suzhou Maximum Bio-tech Co., Ltd. as a novel CAR-T cell therapy targeting B7-H3 for patients with pleural malignant tumors, a niche but significant market segment given the limited treatment options for advanced malignant pleural effusions. The trial's focus on locoregional delivery may enhance therapeutic efficacy while minimizing systemic exposure. The competitive landscape includes other CAR-T therapies and emerging immunotherapies targeting similar malignancies. Successful outcomes could position MT027 favorably in a growing market for advanced cancer therapies, particularly in regions with high incidence rates of pleural malignancies. Diligence should focus on regulatory pathways, potential partnerships, and the scalability of manufacturing processes for CAR-T cells.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT06726564
Indication
Advanced Malignant Solid Tumor
Modality
cell therapy
Target
B7-H3 (CD276), a co-inhibitory molecule involved in immune regulation, targeted by CRISPR/Cas9 edited allogeneic CAR-T cells.
Intervention
MT027 cells suspension
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.