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Clinical trial intelligence report
A Phase I Study of T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728mR in HIV-Infected Patients, With or Without the CCR5 Delta-32 Mutation, Pre-treated With Cyclophosphamide
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Aug 04, 2026
Report code
NCT02388594-Aug 04, 2026
NCT ID
NCT02388594
Status
COMPLETED
Phase
Phase 1
Sponsor
University of Pennsylvania
Executive brief
Investment-Ready Snapshot
The study, sponsored by the University of Pennsylvania, investigates the safety and antiviral activity of genetically modified CD4+ T cells targeting the CCR5 gene in HIV-infected patients. Given the ongoing global HIV epidemic and the limitations of current antiretroviral therapies, this innovative approach could position the sponsor favorably in the competitive landscape of HIV treatments. The potential for a one-time treatment that could lead to sustained viral control may attract significant interest from investors and partners, particularly in light of the growing demand for novel therapies in the HIV space. The collaboration with the National Institute of Allergy and Infectious Diseases (NIAID) further enhances credibility and may facilitate future funding opportunities. However, the market is competitive, with several companies exploring gene editing and immunotherapy approaches for HIV, necessitating careful monitoring of competitor advancements and regulatory pathways.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT02388594
Indication
Human Immunodeficiency Virus (HIV)
Modality
small molecule
Target
CCR5 gene (specifically targeting the CCR5 receptor on CD4+ T cells using Zinc Finger Nucleases)
Intervention
ZFN Modified CD4+ T Cells, Cyclophosphamide
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.