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A Phase I Study of T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728mR in HIV-Infected Patients, With or Without the CCR5 Delta-32 Mutation, Pre-treated With Cyclophosphamide
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 20, 2026
NCT ID
NCT02388594
Status
COMPLETED
Phase
Phase 1
Sponsor
University of Pennsylvania
Executive brief
Investment-Ready Snapshot
The study, sponsored by the University of Pennsylvania, investigates a novel approach to HIV treatment through genetic modification of T-cells. The potential market for HIV therapies remains significant, with ongoing demand for innovative solutions that enhance patient outcomes. Given the competitive landscape, particularly with existing antiretroviral therapies and emerging gene therapies, successful results could position this asset favorably. The collaboration with the National Institute of Allergy and Infectious Diseases (NIAID) may enhance credibility and facilitate future funding or partnership opportunities. Diligence should focus on the safety profile, scalability of the manufacturing process for modified T-cells, and regulatory pathways for gene therapies.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT02388594
Indication
Human Immunodeficiency Virus (HIV)
Modality
small molecule
Target
CCR5 gene modification using Zinc Finger Nucleases (ZFN) to create ZFN Modified CD4+ T Cells.
Intervention
ZFN Modified CD4+ T Cells, Cyclophosphamide
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.