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Clinical trial intelligence report
The Phase I Efficacy and Safety Clinical Study of GPC3-CAR-T Cells in Hepatocellular Carcinoma Patients
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Aug 04, 2026
Report code
NCT04506983-Aug 04, 2026
NCT ID
NCT04506983
Status
SUSPENDED
Phase
Phase 1
Sponsor
Beijing Tsinghua Chang Gung Hospital
Executive brief
Investment-Ready Snapshot
The GPC3-CAR-T cell therapy is positioned within the growing CAR-T cell market, specifically targeting hepatocellular carcinoma (HCC), a prevalent form of liver cancer. Given the limited treatment options for patients who have failed first-line therapies, this asset addresses a significant unmet medical need. The collaboration with China Immunotech (Beijing) Biotechnology Co., Ltd. may enhance development capabilities and market access. However, the trial's current suspension due to plan adjustments raises concerns regarding timelines and resource allocation. Competitive analysis indicates that while there are other CAR-T therapies in development, GPC3's specificity may provide a unique selling proposition if safety and efficacy are demonstrated.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT04506983
Indication
Hepatocellular Carcinoma
Modality
protein therapy
Target
Glypican-3 (GPC3), a cell membrane protein associated with hepatocellular carcinoma.
Intervention
GPC3-CAR-T cells
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.