TrialSignal
Clinical trial intelligence report
An Open-Label, Single-Arm, Dose-Escalation Phase I Study Evaluating the Safety, Tolerability, and Preliminary Efficacy of EDB-102 in Patients With EGFR L858R-Mutant, Third-Generation TKI-Resistant Advanced Non-Small Cell Lung Cancer With Liver Metastases
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Aug 04, 2026
Report code
NCT07461727-Aug 04, 2026
NCT ID
NCT07461727
Status
NOT_YET_RECRUITING
Phase
Phase 1
Sponsor
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Executive brief
Investment-Ready Snapshot
EDB-102 represents a novel approach in the treatment of advanced non-small cell lung cancer (NSCLC) with liver metastases, specifically targeting patients with the EGFR L858R mutation who have shown resistance to third-generation EGFR-TKIs like osimertinib. The market for NSCLC therapies is substantial, with a growing demand for innovative treatments that address resistance mechanisms. The unique mechanism of action of EDB-102 positions it favorably against existing therapies, potentially offering a competitive edge in a crowded market. The study's focus on a specific mutation and patient population may enhance its attractiveness to investors and partners, particularly as the clinical landscape evolves towards personalized medicine.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT07461727
Indication
Non-Small Cell Lung Cancer
Modality
gene therapy
Target
EGFR L858R mutation in tumor cells, utilizing CRISPR-Cas9 gene-editing technology.
Intervention
EDB-102
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.