TrialSignal
Clinical trial intelligence report
A Phase 1b Study of BCL-XL Degrader DT2216 in Combination With Weekly Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 20, 2026
NCT ID
NCT06964009
Status
RECRUITING
Phase
Phase 1b
Sponsor
Elizabeth Stover, MD, PhD
Executive brief
Investment-Ready Snapshot
The clinical trial investigates the combination of DT2216, a BCL-XL degrader, with paclitaxel in patients with recurrent platinum-resistant ovarian cancer. This combination aims to enhance therapeutic efficacy in a patient population with limited treatment options. The market for ovarian cancer therapies is significant, with ongoing demand for innovative treatments that can improve outcomes in resistant cases. The trial is sponsored by Dana-Farber Cancer Institute, with funding from Dialectic Therapeutics and the Department of Defense, indicating strong institutional support and potential for future collaborations. The competitive landscape includes existing therapies like paclitaxel and emerging agents targeting similar pathways, necessitating a thorough analysis of DT2216's safety and efficacy to establish a viable market position.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT06964009
Indication
Ovarian Cancer
Modality
small molecule
Target
BCL-XL protein (via proteolysis-targeting chimera, PROTAC mechanism)
Intervention
DT2216, Paclitaxel
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.