TrialSignal
Clinical trial intelligence report
Autologous TRAC Locus-inserted CD19-targeting Synthetic T-cell Receptor Antigen Receptor T (STAR-T) Cells for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Aug 04, 2026
Report code
NCT05631912-Aug 04, 2026
NCT ID
NCT05631912
Status
UNKNOWN
Phase
Phase 1/2
Sponsor
Chinese PLA General Hospital
Executive brief
Investment-Ready Snapshot
The clinical trial is sponsored by the Chinese PLA General Hospital and aims to evaluate the safety and efficacy of autologous CD19-targeting STAR-T cell therapy in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma (B-NHL). Given the increasing prevalence of B-NHL and the limitations of existing CAR-T therapies, this innovative approach could capture significant market share if proven effective. The trial's unique mechanism of action, which combines elements of CAR and TCR therapies, positions it competitively against established therapies. The trial is currently recruiting, with an estimated completion date in December 2025, indicating a potential for early market entry if successful. Stakeholders should monitor the trial closely for developments that could influence market dynamics and investment opportunities.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT05631912
Indication
Non-hodgkin Lymphoma,B Cell
Modality
protein therapy
Target
CD19-targeting synthetic T-cell receptor (STAR) utilizing CRISPR/Cas9 technology for TRAC locus insertion.
Intervention
Autologous CD19-STAR-T cell, Fludarabine, Cyclophosphamide
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.