NCT05312697TERMINATEDanonymous

A Phase 2b, Multicenter, Long-term Extension Study of Setrusumab in Adults With Type I, III, or IV Osteogenesis Imperfecta

Sponsor

Source record

Ultragenyx Pharmaceutical Inc

Phase

Source record

PHASE2

Modality

AI-normalized

monoclonal antibody

Target

AI-normalized

Setrusumab

Indication / condition

AI-normalized

Osteogenesis Imperfecta

Intervention

Source record

Setrusumab

Related intelligence directories

Indication directory: Osteogenesis Imperfecta Modality directory: monoclonal antibody Target directory: Setrusumab

Source & freshness

Source record

NCT ID

NCT05312697

Original source

ClinicalTrials.gov

Source last updated

Jul 23, 2025

Ingested at

Jun 11, 2026

Internal sync

Jun 11, 2026

Model version

trialsignal-ai-v1

Normalized confidence

96%

Validation status

validated

Open original registry record

View original source fields

NCT ID

NCT05312697

Title

A Phase 2b, Multicenter, Long-term Extension Study of Setrusumab in Adults With Type I, III, or IV Osteogenesis Imperfecta

Sponsor

Ultragenyx Pharmaceutical Inc

Status

TERMINATED

Phase

PHASE2

Condition raw

Osteogenesis Imperfecta

Condition normalized

Osteogenesis Imperfecta

Modality raw

monoclonal antibody

Modality normalized

monoclonal antibody

Target raw

Setrusumab

Target normalized

Setrusumab

Interventions

Setrusumab

Public preview

Source record

The primary objective of the study is to evaluate bone mineral density (BMD) after 12 months of retreatment with monthly setrusumab in adults with osteogenesis imperfecta (OI).

AI-generated analysis supports research triage only. Verify source records, publications, sponsor disclosures and IP databases before making diligence decisions. Model: trialsignal-ai-v1.

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TrialSignal

Clinical trial intelligence report

A Phase 2b, Multicenter, Long-term Extension Study of Setrusumab in Adults With Type I, III, or IV Osteogenesis Imperfecta

Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.

Generated

Jun 20, 2026

NCT ID

NCT05312697

Status

TERMINATED

Phase

PHASE2

Sponsor

Ultragenyx Pharmaceutical Inc

Executive brief

Investment-Ready Snapshot

The primary objective of the study is to evaluate bone mineral density (BMD) after 12 months of retreatment with monthly setrusumab in adults with osteogenesis imperfecta (OI).

Source & freshness

Provenance

SourceClinicalTrials.gov

Source updatedJul 23, 2025

Internal syncJun 11, 2026

Model versiontrialsignal-ai-v1

https://clinicaltrials.gov/study/NCT05312697

Indication

Osteogenesis Imperfecta

Modality

monoclonal antibody

Target

Setrusumab

Intervention

Setrusumab

Source record