TrialSignal
Clinical trial intelligence report
Phase I/II Clinical Trial of CD73/AXL Targeted HypoSti.CAR-T Cells in Treating Patients With CD73/AXL Positive Advanced/Metastatic Solid Tumors
Source-linked diligence brief with registry provenance, taxonomy normalization and premium analytical context.
Generated
Jun 20, 2026
NCT ID
NCT06939270
Status
NOT_YET_RECRUITING
Phase
Phase 1/2
Sponsor
Chinese PLA General Hospital
Executive brief
Investment-Ready Snapshot
The CD73/AXL.HypoSti.CAR-T cell therapy represents a novel approach in the CAR-T landscape, specifically targeting solid tumors that express CD73 and AXL antigens. This dual-targeting strategy aims to overcome challenges associated with solid tumors, such as antigen escape and immunosuppressive tumor microenvironments. The trial is sponsored by the Chinese PLA General Hospital and involves collaboration with Fudan University, indicating a strong institutional backing. Given the increasing prevalence of solid tumors and the limitations of existing therapies, successful outcomes could position this therapy favorably in a competitive market, particularly against other CAR-T therapies and emerging immunotherapies. However, the trial is currently not yet recruiting, and the anticipated timeline for results extends to 2028, which may affect investor interest and market entry timing.
Source & freshness
Provenance
https://clinicaltrials.gov/study/NCT06939270
Indication
Solid Tumor
Modality
cell therapy
Target
CD73 and AXL antigens in advanced/metastatic solid tumors.
Intervention
CD73/AXL.HypoSti.CAR-T cells, Albumin-Bound Paclitaxel, Cyclophosphamide, Fludarabine
Source record
Protocol Description
Detailed source ingestion pending.
Source record
Outcome Measures
Detailed source ingestion pending.
Source record
Eligibility
Detailed source ingestion pending.
AI analysis
Known Results And Readout Context
Detailed source ingestion pending.
IP intelligence
Patent And IP Landscape
Detailed source ingestion pending.
Source record
Contacts
Detailed source ingestion pending.